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Published 3 July 2006. doi:10.1083/jcb.200606024
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 174, Number 1, 7-9
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 Con-nectin axons and dendrites

Gerard M.J. Beaudoin, III

Department of Physiology, University of California, San Francisco, San Francisco, CA 94143

Correspondence to Gerard M.J. Beaudoin III: gerard.beaudoin{at}ucsf.edu

Unlike adherens junctions, synapses are asymmetric connections, usually between axons and dendrites, that rely on various cell adhesion molecules for structural stability and function. Two cell types of adhesion molecules found at adherens junctions, cadherins and nectins, are thought to mediate homophilic interaction between neighboring cells. In this issue, Togashi et al. (see p. 141) demonstrate that the differential localization of two heterophilic interacting nectins mediates the selective attraction of axons and dendrites in cooperation with cadherins.


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Related Article

Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery
Hideru Togashi, Jun Miyoshi, Tomoyuki Honda, Toshiaki Sakisaka, Yoshimi Takai, and Masatoshi Takeichi
J. Cell Biol. 2006 174: 141-151. [Abstract] [Full Text] [PDF]





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