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University of Pennsylvania, Philadelphia, PA 19104

Correspondence to Michael S. Marks: marksm{at}mail.med.upenn.edu

Abstract
Over 60 distinct Rab GTPases regulate specific vesicular transport steps in the mammalian central vacuolar system. Wasmeier et al. (this issue, p. 271) reveal a redundant role for two tissue-specific Rab proteins in regulating transport to a tissue-specific lysosome-related organelle, the melanosome.

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