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Published 18 December 2006. doi:10.1083/jcb.200611149
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 175, Number 6, 849-851
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 Making more microtubules by severing: a common theme of noncentrosomal microtubule arrays?

Antonina Roll-Mecak and Ronald D. Vale

Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158

Correspondence to Ron Vale: vale{at}cmp.ucsf.edu


Abstract
Two related enzymes, katanin and spastin, use the energy from ATP hydrolysis to sever microtubules. Two new studies (one in this issue; see McNally et al., p. 881) show that microtubule severing by katanin provides a means for increasing microtubule density in meiotic spindles. Interestingly, loss of spastin leads to a sparser microtubule array in axons and synaptic boutons. Together, these studies hint at a wider role for microtubule-severing enzymes in the formation and organization of noncentrosomal microtubule arrays by generating new seeds for microtubule growth.


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