Building blood vessels--stem cell models in vascular biology

doi:10.1083/jcb.200701146

Published online May 29, 2007
doi:10.1083/jcb.200701146
The Journal of Cell Biology, Vol. 177, No. 5, 751-755
The Rockefeller University Press, 0021-9525 $30.00
© 2007 Jakobsson et al.

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Building blood vessels—stem cell models in vascular biology

Lars Jakobsson, Johan Kreuger, and Lena Claesson-Welsh

Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden

Correspondence to Lena Claesson-Welsh: Lena.Welsh{at}genpat.uu.se

Spheroids of differentiating embryonic stem cells, denoted embryoidbodies, constitute a high-quality model for vascular development,particularly well suited for loss-of-function analysis of genesrequired for early embryogenesis. This review examines vasculogenesisand angiogenesis in murine embryoid bodies and discusses thepromise of stem cell–based models for the study of humanvascular development.

Abbreviations used in this paper: 2D, two-dimensional; 3D, three-dimensional;EB, embryoid body; EC, endothelial cell; ESC, embryonic stemcell; HS, heparan sulfate; NDST, N-deacetylase N-sulfotransferase;VEGFR, VEGF receptor.

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