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Published online August 6, 2007
doi:10.1083/jcb.200702125
The Journal of Cell Biology, Vol. 178, No. 4, 567-574
The Rockefeller University Press, 0021-9525 $30.00
© 2007 Link et al.
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 A collective form of cell death requires homeodomain interacting protein kinase

Nichole Link, Po Chen, Wan-Jin Lu, Kristi Pogue, Amy Chuong, Miguel Mata, Joshua Checketts, and John M. Abrams

Department of Cell Biology, UT Southwestern Medical Center, Dallas, TX 75390

Correspondence to John Abrams: John.Abrams{at}utsouthwestern.edu

We examined post-eclosion elimination of the Drosophila wing epithelium in vivo where collective "suicide waves" promote sudden, coordinated death of epithelial sheets without a final engulfment step. Like apoptosis in earlier developmental stages, this unique communal form of cell death is controlled through the apoptosome proteins, Dronc and Dark, together with the IAP antagonists, Reaper, Grim, and Hid. Genetic lesions in these pathways caused intervein epithelial cells to persist, prompting a characteristic late-onset blemishing phenotype throughout the wing blade. We leveraged this phenotype in mosaic animals to discover relevant genes and establish here that homeodomain interacting protein kinase (HIPK) is required for collective death of the wing epithelium. Extra cells also persisted in other tissues, establishing a more generalized requirement for HIPK in the regulation of cell death and cell numbers.

N. Link and P. Chen contributed equally to this paper.

Abbreviations used in this paper: FLP, flippase; FRT, FLP recombinase target; HIPK, homeodomain interacting protein kinase; PCD, programmed cell death WT, wild type.


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