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Published online October 8, 2007
doi:10.1083/jcb.200709055
The Journal of Cell Biology, Vol. 179, No. 1, 11-13
The Rockefeller University Press, 0021-9525 $30.00
© 2007 Levine
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 A lipid transfer protein that transfers lipid

Tim P. Levine

University College London Institute of Ophthalmology, London EC1V 9EL, England, UK

Correspondence to Tim P. Levine: tim.levine{at}ucl.ac.uk

Very few lipid transfer proteins (LTPs) have been caught in the act of transferring lipids in vivo from a donor membrane to an acceptor membrane. Now, two studies (Halter, D., S. Neumann, S.M. van Dijk, J. Wolthoorn, A.M. de Maziere, O.V. Vieira, P. Mattjus, J. Klumperman, G. van Meer, and H. Sprong. 2007. J. Cell Biol. 179:101–115; D'Angelo, G., E. Polishchuk, G.D. Tullio, M. Santoro, A.D. Campli, A. Godi, G. West, J. Bielawski, C.C. Chuang, A.C. van der Spoel, et al. 2007. Nature. 449:62–67) agree that four-phosphate adaptor protein 2 (FAPP2) transfers glucosylceramide (GlcCer), a lipid that takes an unexpectedly circuitous route.


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Related Article

Pre- and post-Golgi translocation of glucosylceramide in glycosphingolipid synthesis
David Halter, Sylvia Neumann, Suzanne M. van Dijk, Jasja Wolthoorn, Ann M. de Mazière, Otilia V. Vieira, Peter Mattjus, Judith Klumperman, Gerrit van Meer, and Hein Sprong
J. Cell Biol. 2007 179: 101-115. [Abstract] [Full Text] [PDF]





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