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Published online October 15, 2007
doi:10.1083/jcb.200705106
The Journal of Cell Biology, Vol. 179, No. 2, 183-186
The Rockefeller University Press, 0021-9525 $30.00
© 2007 Weterings et al.
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 DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys?

Eric Weterings and David J. Chen

Division of Molecular Radiation Biology, Department of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390

Correspondence to David J. Chen: david.chen{at}utsouthwestern.edu

The DNA-dependent protein kinase (DNA-PK) is one of the central enzymes involved in DNA double-strand break (DSB) repair. It facilitates proper alignment of the two ends of the broken DNA molecule and coordinates access of other factors to the repair complex. We discuss the latest findings on DNA-PK phosphorylation and offer a working model for the regulation of DNA-PK during DSB repair.

Abbreviations used in this paper: ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia related protein; DSB, double-strand break; HR, homologous recombination; NHEJ, nonhomologous end joining.


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