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Published online October 22, 2007
doi:10.1083/jcb.200704141
The Journal of Cell Biology, Vol. 179, No. 2, 277-290
The Rockefeller University Press, 0021-9525 $30.00
© 2007 Siegl-Cachedenier et al.
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Article

 Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres

Irene Siegl-Cachedenier, Ignacio Flores, Peter Klatt, and Maria A. Blasco

Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Center, Madrid, E-28029, Spain

Correspondence to Maria A. Blasco: mblasco{at}cnio.es

Organ homeostasis and organismal survival are related to the ability of stem cells to sustain tissue regeneration. As a consequence of accelerated telomerase shortening, telomerase-deficient mice show defective tissue regeneration and premature death. This suggests a direct impact of telomere length and telomerase activity on stem cell biology. We recently found that short telomeres impair the ability of epidermal stem cells to mobilize out of the hair follicle (HF) niche, resulting in impaired skin and hair growth and in the suppression of epidermal stem cell proliferative capacity in vitro. Here, we demonstrate that telomerase reintroduction in mice with critically short telomeres is sufficient to correct epidermal HF stem cell defects. Additionally, telomerase reintroduction into these mice results in a normal life span by preventing degenerative pathologies in the absence of increased tumorigenesis.

Abbreviations used in this paper: a.u.f., arbitrary units of fluorescence; HF, hair follicle; IFE, interfollicular epidermis; LRC, label retaining cell; MEF, mouse embryonic fibroblast; Q-FISH, quantitative FISH; TPA, 12-O-tetradecanoylphorbol- 13-acetate.


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