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Published online November 5, 2007
doi:10.1083/jcb.200710062
The Journal of Cell Biology, Vol. 179, No. 3, 367-369
The Rockefeller University Press, 0021-9525 $30.00
© 2007 Motegi et al.
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 Revisiting the role of microtubules in C. elegans polarity

Fumio Motegi and Geraldine Seydoux

Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Center for Cell Dynamics, Johns Hopkins School of Medicine, Baltimore, MD 21205

Correspondence to Fumio Motegi: fmotegi1{at}jhmi.edu; or Geraldine Seydoux: gseydoux{at}jhmi.edu

Cells must break symmetry to acquire polarity. Microtubules have been implicated in the induction of asymmetry in several cell types, but their role in the Caenorhabditis elegans zygote, a classic polarity model, has remained uncertain. One study (see Tsai and Ahringer on p. 397 of this issue) brings new light to this problem by demonstrating that severe loss of microtubules impairs polarity onset in C. elegans.


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Microtubules are involved in anterior-posterior axis formation in C. elegans embryos
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J. Cell Biol. 2007 179: 397-402. [Abstract] [Full Text] [PDF]





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