JCB logo
Track the topics, authors and articles important to you
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online November 5, 2007
doi:10.1083/jcb.200707101
The Journal of Cell Biology, Vol. 179, No. 3, 527-537
The Rockefeller University Press, 0021-9525 $30.00
© 2007 Rybkin et al.
This Article
Right arrow Full Text
Right arrow PDF (Full Text)
Right arrow PPT slides of all figures
Right arrow Supplemental Material Index
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Rybkin, I. I.
Right arrow Articles by Olson, E. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Rybkin, I. I.
Right arrow Articles by Olson, E. N.
Related Collections
Right arrowRelated Article
Right arrowRelated In this Issue article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Article

 Regulation of atrial natriuretic peptide secretion by a novel Ras-like protein

Igor I. Rybkin1, Mi-Sung Kim1, Svetlana Bezprozvannaya1, Xiaoxia Qi1, James A. Richardson2, Craig F. Plato4, Joseph A. Hill3, Rhonda Bassel-Duby1, and Eric N. Olson1

1 Department of Molecular Biology, 2 Department of Pathology, and 3 Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390
4 Gilead-Colorado, Westminster, CO 80021

Correspondence to Eric N. Olson: eric.olson{at}utsouthwestern.edu

Atrial cardiomyocytes, neurons, and endocrine tissues secrete neurotransmitters and peptide hormones via large dense-core vesicles (LDCVs). We describe a new member of the Ras family of G-proteins, named RRP17, which is expressed specifically in cardiomyocytes, neurons, and the pancreas. RRP17 interacts with Ca2+-activated protein for secretion-1 (CAPS1), one of only a few proteins known to be associated exclusively with LDCV exocytosis. Ectopic expression of RRP17 in cardiomyocytes enhances secretion of atrial natriuretic peptide (ANP), a regulator of blood pressure and natriuresis. Conversely, genetic deletion of RRP17 in mice results in dysmorphic LDCVs, impaired ANP secretion, and hypertension. These findings identify RRP17 as a component of the cellular machinery involved in regulated secretion within the heart and potential mediator of the endocrine influence of the heart on other tissues.

Abbreviations used in this paper: ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; C2, calcium binding domain; CAPS1, calcium-activated protein for secretion 1; CNP, C-type natriuretic peptide; DCV, dense-core vesicle; DNP, dendroaspis natriuretic peptide; GNB, guanine nucleotide binding domain; LDCV, large dense-core vesicles; MHD, munc homology domain; NP, natriuretic peptide; PH, pleckstrin homology; RRP17, Ras-related protein 17; TAB, thoracic aortic banding.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

Getting a G–RRP on regulated exocytosis in the heart
Christopher C. Glembotski
J. Cell Biol. 2007 179: 371-373. [Abstract] [Full Text] [PDF]

Related In this Issue article

Heart hormone release
Ruth Williams
J. Cell Biol. 2007 179: 361. [Full Text] [PDF]



This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents