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Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065

Correspondence to Elaine Fuchs: fuchslb{at}rockefeller.edu

The skin epidermis and its appendages provide a protective barrier that is impermeable to harmful microbes and also prevents dehydration. To perform their functions while being confronted with the physicochemical traumas of the environment, these tissues undergo continual rejuvenation through homeostasis, and, in addition, they must be primed to undergo wound repair in response to injury. The skin's elixir for maintaining tissue homeostasis, regenerating hair, and repairing the epidermis after injury is its stem cells, which reside in the adult hair follicle, sebaceous gland, and epidermis. Stem cells have the remarkable capacity to both self-perpetuate and also give rise to the differentiating cells that constitute one or more tissues. In recent years, scientists have begun to uncover the properties of skin stem cells and unravel the mysteries underlying their remarkable capacity to perform these feats. In this paper, I outline the basic lineages of the skin epithelia and review some of the major findings about mammalian skin epithelial stem cells that have emerged in the past five years.

Abbreviations used in this paper: BMP, bone morphogenetic protein; BMPR, BMP receptor; DP, dermal papillae; E-cadherin, epithelial cadherin; EDA, ectodysplasin; EGFR, EGF receptor; EPU, epidermal proliferative unit; FA, focal adhesion; IRS, inner root sheath; ORS, outer root sheath; RTK, receptor tyrosine kinase; SG, sebaceous gland; Shh, Sonic hedgehog; TA, transit amplifying.

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Cell biology of stem cells: an enigma of asymmetry and self-renewal

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This article has been cited by other articles:

• Fuchs, E. (2008). Skin stem cells: rising to the surface. J. Exp. Med. 205: i5-i5 [Full Text]  
• Lin, H. (2008). Cell biology of stem cells: an enigma of asymmetry and self-renewal. J. Cell Biol. 180: 257-260 [Abstract] [Full Text]  

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