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Published online February 18, 2008
doi:10.1083/jcb.200711022
The Journal of Cell Biology, Vol. 180, No. 4, 721-728
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Wang et al.
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 The JAK/STAT pathway positively regulates DPP signaling in the Drosophila germline stem cell niche

Liwei Wang1, Zhouhua Li1, and Yu Cai1,2

1 Temasek Lifesciences Laboratory, National University of Singapore, Singapore 117604
2 Department of Biological Science, National University of Singapore, Singapore 117543

Correspondence to Correspondence to Yu Cai: caiyu{at}tll.org.sg

The stem cell niche, formed by surrounding stromal cells, provides extrinsic signals that maintain stem cell self-renewal. However, it remains unclear how these extrinsic signals are regulated. In the Drosophila female germline stem cell (GSC) niche, Decapentaplegic (DPP) is an important niche factor for GSC self-renewal. The exact source of the DPP and how its transcription is regulated in this niche remain unclear. We show that dpp is expressed in somatic cells of the niche including the cap cells, a subtype of niche cells. Furthermore, our data show that the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway positively regulates dpp expression in the cap cells, suggesting that JAK/STAT activity is required in somatic niche cells to prevent precocious GSC differentiation. Our data suggest that the JAK/STAT pathway functions downstream/independently of cap cell formation induced by Notch signaling. JAK/STAT signaling may also regulate dpp expression in the male GSC niche, suggesting a common origin of female and male GSC niches.

Abbreviations used in this paper: bam, bag-of-marbles; CB, cystoblast; Dad, daughters against DPP; DPP, Decapentaplegic; ESC, escort stem cell; GSC, germline stem cell; JAK/STAT, Janus kinase/signal transducer and activator of transcription; N, Notch; SSC, somatic stem cell; TF, terminal filament.


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