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Published online March 31, 2008
doi:10.1083/jcb.200708176
The Journal of Cell Biology, Vol. 181, No. 1, 89-103
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Nakajima et al.
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Article

 Myt1 protein kinase is essential for Golgi and ER assembly during mitotic exit

Hiroyuki Nakajima1, Shigenobu Yonemura2, Masayuki Murata3, Nobuhiro Nakamura4, Helen Piwnica-Worms5,6, and Eisuke Nishida1

1 Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan
2 Laboratory for Cellular Morphogenesis, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan
3 Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Tokyo 153-8902, Japan
4 Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa 920-1192, Japan
5 Department of Cell Biology and Physiology and 6 Department of Internal Medicine, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, MO 63110

Correspondence to Eisuke Nishida: L50174{at}sakura.kudpc.kyoto-u.ac.jp

Myt1 was originally identified as an inhibitory kinase for Cdc2 (Cdk1), the master engine of mitosis, and has been thought to function, together with Wee1, as a negative regulator of mitotic entry. In this study, we report an unexpected finding that Myt1 is essential for Golgi and endoplasmic reticulum (ER) assembly during telophase in mammalian cells. Our analyses reveal that both cyclin B1 and cyclin B2 serve as targets of Myt1 for proper Golgi and ER assembly to occur. Thus, our results show that Myt1-mediated suppression of Cdc2 activity is not indispensable for the regulation of a broad range of mitotic events but is specifically required for the control of intracellular membrane dynamics during mitosis.


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