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Published online April 14, 2008
doi:10.1083/jcb.200803120
The Journal of Cell Biology, Vol. 181, No. 2, 181-183
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Seed et al.
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 Spinophilin and the immune synapse

Brian Seed1 and Ramnik Xavier2

1 Department of Pediatrics and 2 Department of Medicine, Center for Computational and Integrative Biology, Massachusetts General Hospital, Boston, MA 02114

Correspondence to B. Seed: bseed{at}ccib.mgh.harvard.edu

Extensive alterations in cellular organization are known to accompany the responses of sensitized T cells to target cells presenting an antigen of interest. Now, equally if not more dramatic changes are found to take place in cells presenting an antigen. With the help of a spinophilin-GFP fusion protein, Bloom et al. (Bloom, O., J.J. Unternaehrer, A. Jiang, J.-S. Shin, L. Delamarre, P. Allen, and I. Mellman. 2008. J. Cell Biol. 181:203–211) have captured a remarkable polarization of the cellular architecture of dendritic cells presenting an antigen to T cells.

Abbreviation used in this paper: GPCR, G protein–coupled receptor.


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Related Article

Spinophilin participates in information transfer at immunological synapses
Ona Bloom, Julia J. Unternaehrer, Aimin Jiang, Jeong-Sook Shin, Lélia Delamarre, Patrick Allen, and Ira Mellman
J. Cell Biol. 2008 181: 203-211. [Abstract] [Full Text] [PDF]





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