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Published online May 19, 2008
doi:10.1083/jcb.200804136
The Journal of Cell Biology, Vol. 181, No. 4, 575-577
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Salzer
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 Switching myelination on and off

James L. Salzer

Department of Cell Biology and Neurology, Smilow Neuroscience Program, New York University School of Medicine, New York, NY 10016

Correspondence to James L. Salzer: Salzer{at}Saturn.med.nyu.edu

Schwann cells are remarkably plastic cells that can both form and stably maintain myelin sheaths around axons and also rapidly dedifferentiate upon injury. New findings (Parkinson, D.B., A. Bhaskaran, P. Arthur-Farraj, L.A. Noon, A. Woodhoo, A.C. Lloyd, M.L. Feltri, L. Wrabetz, A. Behrens, R. Mirsky, and K.R. Jessen. 2008. J. Cell Biol. 181:625–637) indicate that the transition between these distinct states of differentiation is directed by the transcription factor Krox-20, which promotes and maintains myelination, and c-Jun, which antagonizes it. Cross-inhibition of these transcription factors serves to switch Schwann cells between the myelinated and dedifferentiated phenotypes, respectively.

Abbreviation used in this paper: MKK, MAPK kinase.


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Related Article

c-Jun is a negative regulator of myelination
David B. Parkinson, Ambily Bhaskaran, Peter Arthur-Farraj, Luke A. Noon, Ashwin Woodhoo, Alison C. Lloyd, M. Laura Feltri, Lawrence Wrabetz, Axel Behrens, Rhona Mirsky, and Kristján R. Jessen
J. Cell Biol. 2008 181: 625-637. [Abstract] [Full Text] [PDF]





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