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Published online June 2, 2008
doi:10.1083/jcb.200802107
The Journal of Cell Biology, Vol. 181, No. 5, 719-726
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Rusan et al.
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Mini-Review

 Original CIN: reviewing roles for APC in chromosome instability

Nasser M. Rusan1 and Mark Peifer1,2

1 Department of Biology and 2 Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599

Correspondence to Mark Peifer: peifer{at}unc.edu

You may have seen the bumper sticker "Eve was framed." Thousands of years of being blamed for original sin and still many wonder, where's the evidence? Today, the tumor suppressor adenomatous polyposis coli (APC) may have the same complaint about accusations of a different type of CIN, chromosome instability. A series of recent papers, including three in this journal, propose that loss of APC function plays an important role in the CIN seen in many colon cancer cells. However, a closer look reveals a complex story that raises more questions than answers.

Abbreviations used in this paper: ABI, anaphase bridge index; APC, adenomatous polyposis coli; CIN, chromosome instability; ES, embryonic stem; MCAK, mitotic centromere-associated kinesin; MT, microtubule; SAC, spindle assembly checkpoint; TCF, T cell factor.


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