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J. Biophys. and Biochem. Cytol., Vol 2, 179-184, Copyright © 1956 by Rockefeller University Press

ARTICLE

ELECTRON MICROSCOPY OF LYSOSOME-RICH FRACTIONS FROM RAT LIVER

Alex B. Novikoff Ph.D.1, H. Beaufay M.D.1, and C. de Duve M.D.1

1 From the Department of Pathology, Albert Einstein College of Medicine, Yeshiva University, New York, and the Department of Physiological Chemistry, University of Louvain, Belgium

A preliminary electron microscope study has revealed the presence in lysosome-rich fractions, isolated from rat liver, of hitherto undescribed cytoplasmic particles, called "dense bodies."

Approximately 0.37 µ in length, the dense bodies often possess an internal cavity and external membrane. They contain many electron-dense granules 55 to 77 A, or less, in diameter.

Such dense bodies are also visible in electron micrographs of parenchymatous cells in liver sections.

The correlations between dense bodies and lysosomes are listed, but until pure preparations are available it is not possible to assert that dense bodies and lysosomes are identical.


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