ARTICLE

THE CELL GENERATION CYCLE OF THE ELEVEN-DAY MOUSE EMBRYO

M. Atlas Ph.D.¹ and V. P. Bond M.D.¹

¹ From the Department of Biology, Yeshiva University, New York, New York, and The Medical Department, Brookhaven National Laboratory, Upton, Long Island, New York

The incorporation of tritiated thymidine into the DNA of erythroblasts, primitive ependymal cells, and mesenchymal cells of 11-day mouse embryos was studied by radioautography at different times between 25 minutes and 18 hours after injection intraperitoneally. There was no labeling of mitotic figures until 1 hour after injection. Following this, mitotic figures were labeled for about 5.5 hours in primitive ependymal cells and mesenchymal cells, and for a longer period in erythroblasts. The percentage of the labeled primitive ependymal cells at various times after injection indicate a periodic migration into and out of the mitotic zone. The cell generation cycle of primitive ependymal cells and mesenchymal cells is similar to some kinds of adult cells. The cycle of the erythroblasts is more like that of the cells of aging mice.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Hodge, R. D., D'Ercole, A. J., O'Kusky, J. R. (2004). Insulin-Like Growth Factor-I Accelerates the Cell Cycle by Decreasing G1 Phase Length and Increases Cell Cycle Reentry in the Embryonic Cerebral Cortex. J. Neurosci. 24: 10201-10210 [Abstract] [Full Text]  
• Lukaszewicz, A., Savatier, P., Cortay, V., Kennedy, H., Dehay, C. (2002). Contrasting Effects of Basic Fibroblast Growth Factor and Neurotrophin 3 on Cell Cycle Kinetics of Mouse Cortical Stem Cells. J. Neurosci. 22: 6610-6622 [Abstract] [Full Text]  
• Hamilton, A. I. (1969). Cell Population Kinetics: A Modified Interpretation of the Graph of Labeled Mitoses. Science 164: 952-954 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents