ARTICLE

REVERSAL BY ADENINE OF THE ETHIONINE-INDUCED LIPID ACCUMULATION IN THE ENDOPLASMIC RETICULUM OF THE RAT LIVER : A Preliminary Report

Corrado M. Baglio ¹ and Emmanuel Farber ¹

¹ From the Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania

Within 3.5 to 4 hours after thionine administration, numerous small osmiophilic bodies, liposomes, appear in the endoplasmic reticulum of the liver cells. By fusion, the liposomes lead to the formation of larger collections of fat, giant liposomes. Adenine administration to ethionine-treated rats removes the liposomes from the hepatocytes and causes the transitory appearance of osmiophilic droplets in the sinusoidal space of Disse. The characteristic disaggregation of hepatic polysomes seen in the liver after ethionine administration is corrected by the injection of adenine.

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This article has been cited by other articles:

• Stewart, G. A., Farber, E. (1967). Reformation of Functional Liver Polyribosomes from Ribosome Monomers in the Absence of RNA Synthesis. Science 157: 67-69 [Abstract]  

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