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J. Biophys. and Biochem. Cytol., Vol 3, 559-566, Copyright © 1957 by Rockefeller University Press

ARTICLE

THE EFFECTS OF FLUORIDE FEEDING ON THE ORGANIC MATRIX OF BONES AND TEETH OF PIGS AS OBSERVED BY AUTORADIOGRAPHY AFTER IN VITRO UPTAKE OF CA45 AND S35

L. F. Bélanger M.D.1, W. J. Visek Ph.D.1, W. E. Lotz 1, and C. L. Comar Ph.D.1

1 (From the Department of Histology and Embryology, University of Ottawa, Canada, and the Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge, Tennessee)

Demineralized sections of fluorinated bones and teeth have been studied by autoradiography following in vitro uptake of Ca45 or S35O4.

The portions of tissue which do not become mineralized (cartilage, prebone, predentine, and precementum) show an increased Ca45 uptake apparently related to an increase in chondroitin sulfate content in fluorosis.

The tissues from the fluoride-fed animals show an increase of in vitro uptake of sulfur in the tissues which become mineralized (bone, dentine, cementum).

 Submitted on December 6, 1956


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