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J. Biophys. and Biochem. Cytol., Vol 3, 685-695, Copyright © 1957 by Rockefeller University Press

ARTICLE

COLLAGEN BIOSYNTHESIS : TISSUE CULTURE EXPERIMENTS TO ASCERTAIN THE ROLE OF ASCORBIC ACID IN COLLAGEN FORMATION



J. Frederick Woessner Ph.D.1 and Bernard S. Gould Ph.D.1

1 From the Division of Biochemistry, Department of Biology, Massachusetts Institute of Technology, Cambridge

Quantitative studies of collagen formation by chick embryonic lung tissue grown in media deficient in, or completely lacking, ascorbic acid have been carried out. Cell growth and collagen formation in such cultures can proceed almost normally in media lacking ascorbic acid. Ascorbic acid in combination with whole embryo extract, dialyzed media, or synthetic mixture number 703 was found to have no appreciable effect on cell growth or total collagen formation. This is in marked contrast to the almost total failure of collagen formation in scorbutic animals and suggests that for slow collagen biosynthesis as distinct from more prolific collagen-producing systems, ascorbic acid plays an indirect role.

Submitted on March 18, 1957


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