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The Journal of Cell Biology, Vol 31, 349-362, Copyright © 1966 by Rockefeller University Press

ARTICLE

THE STRUCTURE OF EOSINOPHIL LEUKOCYTE GRANULES IN RODENTS AND IN MAN

Fritz Miller 1, Etienne de Harven 1, and George E. Palade 1

1 From the Pathologisches Institut der Universität München, Germany, the Sloan-Kettering Institute for Cancer Research, New York, and The Rockefeller University, New York

The structure of the specific granules of eosinophil leukocytes has been studied by electron microscopy in sections of tissues, buffy coats, and sediments of peritoneal washings of rats, mice, guinea pigs, and men. The core of eosinophil granules is a crystal which has a cubic lattice with a repeat of sim30 A in rodents and sim40 A in man. The chemical composition of the core is discussed in connection with recent cell fractionation studies, and the hypothesis that the core is a crystal of peroxidase is considered.

Submitted on December 14, 1965


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