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The Journal of Cell Biology, Vol 36, 329-339, Copyright © 1968 by Rockefeller University Press

ARTICLE

THE CENTRIOLE CYCLE IN SYNCHRONIZED HELA CELLS

Elliott Robbins 1, Gisela Jentzsch 1, and Anita Micali 1

1 From the Departments of Cell Biology, Microbiology, and Immunology, the Albert Einstein College of Medicine, Bronx, New York 10461

Progression of the HeLa cell through its life cycle is accompanied by centriolar replication and pericentriolar changes that are in synchrony with DNA synthesis and mitosis. The first signs of preparation for replication occur during G1 at which time the two orthogonal centrioles separate. Replication by budding begins at/or near the initiation of DNA synthesis and is completed by G2. Pericentriolar changes which probably are causally related to spindle tubule formation occur at this time and include the appearance of vesicles, electron-opaque bodies, and an amorphous pericentriolar halo. These phenomena begin to disappear by late prophase, and the remainder of mitosis manifests decreasing centriolar and pericentriolar activity.

Submitted on August 9, 1967
Revised on October 3, 1967


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