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The Journal of Cell Biology, Vol 40, 225-235, Copyright © 1969 by Rockefeller University Press

ARTICLE

HORMONE STORAGE GRANULES IN THE BEEF ANTERIOR PITUITARY : I. Isolation, Ultrastructure, and Some Biochemical Properties



Joseph T. Tesar 1, Harold Koenig 1, and Charles Hughes 1

1 From the Neurology Service, the Veterans Administration Research Hospital and the Department of Neurology and Psychiatry and the Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611

A method is described for isolation of relatively large quantities of large and small hormone storage granules from the beef adenohypophysis. The hormone storage granules are highly purified, as indicated by ultrastructural and biochemical criteria. The average size of large granules is 400 mµ and of small granules is 220 mµ. The large granules contain growth hormone and prolactin; the small granules contain high concentrations of follicle-stimulating, luteinizing, and thyroid-stimulating hormones. An alkaline protease with a pH optimum of 8.3 is associated with the small granule fraction.

Submitted on July 5, 1968
Revised on August 6, 1968


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