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The Journal of Cell Biology, Vol 43, 448-455, Copyright © 1969 by Rockefeller University Press

ARTICLE

OPTICAL DIFFRACTION STUDIES OF CRYSTALLINE STRUCTURES IN ELECTRON MICROGRAPHS : II. Crystalline Inclusions in Mitochondria of Human Hepatocytes



Irmin Sternlieb 1 and Jacob E. Berger 1

1 From the Department of Medicine, Albert Einstein College of Medicine and Bronx Municipal Hospital Center, Bronx, New York 10461, and the Center for Crystallographic Research, Roswell Park Division of Health Research, Inc., Buffalo, New York 14203

Unit cell dimensions of mitochondrial crystals were determined by optical diffraction analysis of electron micrographs of human liver biopsy specimens. Identical unit cells were found in pathologic material obtained from six patients with Wilson's disease, from one patient with sickle-cell hepatitis, and from two normal subjects. These measurements led to the conclusion that the crystals observed in patients and in normal subjects were probably chemically identical. Furthermore, the relatively large size of the unit cell limits the choices for its constituents to phospholipid micelles or to relatively large protein molecules.

Submitted on April 11, 1969
Revised on July 23, 1969


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