ARTICLE

A COMPARISON OF THE HETEROGENEOUS NUCLEAR RNA OF HELA CELLS IN DIFFERENT PERIODS OF THE CELL GROWTH CYCLE

Gerassimos N. Pagoulatos ¹ and James E. Darnell ¹

¹ From the Department of Biochemistry, Albert Einstein College of Medicine, New York 10461, and the Department of Biological Sciences, Columbia University, New York 10027

HeLa cells synthesize heterogeneous nuclear RNA (HnRNA) in the G₁, S, and G₂ portions of the cell cycle. HnRNA prepared from these various periods was compared by RNA-DNA hybridization experiments. The results indicated that some of the HnRNA molecules were equivalent at all times in the cell cycle, but limitations in the sensitivity of the hydridization reactions, as well as in the spectrum of hybridizing molecules, restrict the conclusions that can be drawn from these comparisons.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Jelinek, W., Molloy, G., Salditt, M., Wall, R., Sheiness, D., Darnell, J. E. Jr. (1974). Origin of mRNA in HeLa Cells and the Implications for Chromosome Structure. Cold Spring Harb Symp Quant Biol 38: 891-898 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents