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The Journal of Cell Biology, Vol 45, 91-99, Copyright © 1970 by Rockefeller University Press

ARTICLE

LOW-RESISTANCE JUNCTIONS BETWEEN CANCER CELLS IN VARIOUS SOLID TUMORS

Judson D. Sheridan 1

1 From the Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, and Department of Zoology, University of Minnesota, Minneapolis, Minnesota 55455.

The author's present address is University of Minnesota.

Electrical coupling, which reveals the presence of specialized low-resistance intercellular junctions, has now been found in four types of tumors, Sarcoma 180, Novikoff hepatoma, and Morris hepatomas 3924-A and 7777. Coupled cancer cells were distinguished from coupled normal cells by intracellular marking techniques. Although the evidence suggests that coupling may be extensive in some cases, it is not possible to say that the coupling was normal. In particular, the results do not exclude less obvious defects in the specialized junctions, such as abnormal distribution or decreased permeability to molecules other than small inorganic ions. The results are discussed in relation to previous studies of coupling in Novikoff hepatomas and in cultures of S1801 and II cell lines.

Submitted on May 23, 1969
Revised on September 2, 1969


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