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The Journal of Cell Biology, Vol 47, 593-603, Copyright © 1970 by Rockefeller University Press

ARTICLE

THE CHEMICAL NATURE OF KERATOHYALIN GRANULES OF THE EPIDERMIS

A. Gedeon Matoltsy 1 and Margit N. Matoltsy 1

1 From the Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118

Keratohyalin granules were isolated in the native form from the epidermis of newborn rats by the use of citric acid and a detergent. The isolated granules revealed a fine granular substructure in the electron microscope similar to that seen in situ. Analyses of amino acids by automated column-chromatography showed that proline and cystine are present in large proportions whereas histidine is present in a small amount. Accordingly, it was concluded that keratohyalin represents a sulfur-rich amorphous precursor of the horny cell content, rather than a sulfur-poor side product of the keratinization process, or a unique histidine-rich protein as proposed by in situ histochemical and radioautographic studies.

Submitted on March 30, 1970
Revised on June 24, 1970


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