ARTICLE

STUDIES OF THE TRIAD : II. Penetration of Tracers into the Junctional Gap

Clara Franzini-Armstrong ¹

¹ From the Departments of Physiology and Anatomy, Duke University Medical Center, Durham, North Carolina 27706.

Dr. Franzini-Armstrong's present address is the Department of Physiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14620

Ferritin and Imferon molecules were introduced as tracers inside "skinned" muscle fibers to test which part of the triadic junction gap is freely exchangeable with the sarcoplasm. At least 50% of the T-system surface is freely accessible from the sarcoplasm. Of the remainder, 30% of the total T-system surface is covered by the junctional feet, and 20% in the center of the junction may or may not be accessible. The possibility is discussed that the triadic junction may not function as an electrical coupling.

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