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Epitomics: The Rabbit Monoclonal Company
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The Journal of Cell Biology, Vol 49, 380-389, Copyright © 1971 by Rockefeller University Press

ARTICLE

ERYTHROPOIESIS DURING AMPHIBIAN METAMORPHOSIS : II. Immunochemical Study of Larval and Adult Hemoglobins of Rana catesbeiana



George M. Maniatis 1 and Vernon M. Ingram 1

1 From the Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Rabbit antibodies were prepared against the major hemoglobin components of the larval and adult stages of R. catesbeiana. The properties of the antisera were studied by double immunodiffusion, precipitation, and complement fixation. The antisera to tadpole and frog hemoglobins did not cross-react with either hemoglobin or apohemoglobin. The anti-serum against frog hemoglobin was used for the detection of frog hemoglobin in tadpoles undergoing either natural or thyroxine-induced metamorphosis. It was shown that frog hemoglobin is detectable first in the liver, indicating that the liver is the site of erythrocyte maturation during metamorphosis.

Submitted on August 10, 1970
Revised on November 30, 1970


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