J. Biophys. and Biochem. Cytol., Vol 5, 143-151, Copyright © 1959 by Rockefeller University Press
ARTICLE
Abnormal Intranuclear and Cytoplasmic Formations Associated with a Chemically Induced, Transplantable Chicken Sarcoma
Marlene Friedlaender Binggeli Ph.D.1
1 From the Institut de Recherches sur le Cancer, Villejuif (Seine), France
Thirty GRCH/15 tumors (a 1, 2, 5, 6-dibenzanthracene-induced chicken sarcoma) were examined in the light and the electron microscope.
Associated with the sarcoma were two types of abnormal intranuclear lesions, one in the form of a vacuole, the other as an aggregate containing glycogen. In the electron microscope, one type of lesion observed showed an organized microfibrillar structure.
Abnormal cytoplasmic formations occurred as massed clusters of thread-like or tubular material, which gave rise to small bodies with concentric shell structure; similar bodies were found associated with vacuoles.
Submitted on July 15, 1958
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