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The Journal of Cell Biology, Vol 56, 129-138, Copyright © 1973 by Rockefeller University Press

ARTICLE

ELECTRON MICROSCOPE LOCALIZATION OF NUCLEAR RNA'S THAT SHUTTLE BETWEEN CYTOPLASM AND NUCLEUS AND NUCLEAR RNA'S THAT DO NOT

Gary E. Wise 1 and Lester Goldstein 1

1 From the Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado 80302.

Dr. Wise's present address is the Department of Biological Structure, School of Medicine, University of Miami, Miami, Florida 33152

Nuclear transplantations and electron microscope autoradiographv (EMRA) were utilized in order to localize and characterize small nuclear RNA's (snRNA) in ameba nuclei. A class of nonmigrating low molecular weight nuclear RNA's is associated with the structureless region of the nucleoplasm but not with the nucleoli, nuclear helices, or chromatin Thus, the role of these RNA's in genetic regulation is questionable A class of migrating RNA's (presumed, but not directly shown, to be low molecular weight) that shuttles between nucleus and cytoplasm is also not associated with nucleoli or helices but some radioactivity is associated with the chromatin It may be, therefore, that the shuttling RNA's are in some way involved in genetic transcription or replication.

Submitted on July 5, 1972
Revised on August 16, 1972


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