ARTICLE

CEREBELLAR ALTERATIONS IN THE WEAVER MOUSE

Asao Hirano ¹ and Herbert M. Dembitzer ¹

¹ From the Department of Pathology, Montefiore Hospital and Medical Center and Albert Einstein College of Medicine, Bronx, New York 10467

The fine structure of the cerebellum of weaver mouse was examined and the paucity of granule cells and their axons, the parallel fibers, was confirmed. Unexpectedly, however, the dendritic spines of the Purkinje cells which, in normal animals, are the postsynaptic mates of the parallel fibers, were present. Furthermore, their essential morphology and their staining reactions were indistinguishable from those of the Purkinje cell dendritic spines in normal animals. Possible mechanisms of development are discussed.

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