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The Journal of Cell Biology, Vol 56, 659-665, Copyright © 1973 by Rockefeller University Press

ARTICLE

STUDIES ON CELL ADHESION : III. Adhesion of Baby Hamster Kidney Cells



Frederick Grinnell 1, Mary Milam 1, and Paul A. Srere 1

1 From the Cell Biology Unit, Veterans Administration Hospital and Departments of Biochemistry and Cell Biology, The University of Texas Southwestern Medical School, Dallas, Texas 75216

Normal and transformed baby hamster kidney (BHK) cells attach to Falcon polystyrene with the same first order rate constant. The longer the cells are attached to the bottles, the more difficult they are to remove. Sulfhydryl (—SH) binding reagents inhibit both the attachment of BHK cells and the increase in adhesive strength of attached cells. Attached BHK cells bind fewer molecules of [1-14C]N-ethylamleimide (an —SH binding reagent) than do suspended cells. Incubation of cells with high concentrations of trypsin results in a reversible loss of cell adhesiveness. The recovery of adhesiveness of trypsin-treated cells is inhibited by cycloheximide.

Submitted on July 18, 1972
Revised on October 19, 1972


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