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The Journal of Cell Biology, Vol 57, 148-158, Copyright © 1973 by Rockefeller University Press

ARTICLE

THE DIFFERENTIAL EFFECT OF ACTINOMYCIN D IN NORMAL AND VIRUS-TRANSFORMED CELLS

J. G. Williams 1 and I. A. MacPherson 1

1 From the Imperial Cancer Research Fund Laboratories, Lincoln's Inn Fields, London, England

Actinomycin D (AMD) at concentrations up to 0,25 µg/ml shows a differential effect on cell RNA synthesis and on the replication of an influenza virus in normal and virally transformed cells, both functions being more resistant to AMD in the transformed cell. A possible explanation for these differences in AMD sensitivity is provided by the observation that isotopically labeled AMD is maintained at a lower concentration in transformed BHK 21/13 (BHK) cells. There is evidence that the decreased sensitivity of the transformed cells to AMD is a result of maintenance of a lower internal concentration of the drug, since a correlation exists for a number of polyoma virus-transformed clones between sensitivity to and uptake of AMD.

Submitted on August 21, 1972
Revised on October 10, 1972


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