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The Journal of Cell Biology, Vol 57, 16-26, Copyright © 1973 by Rockefeller University Press

ARTICLE

ELECTRON MICROSCOPE AUTORADIOGRAPHY OF ERYTHROID CELLS USING RADIOACTIVE IRON

D. M. Parry 1 and N. M. Blackett 1

1 From the Biophysics Division, Institute of Cancer Research, Sutton, Surrey, England

The "circle analysis" method of Williams (1969) and a new improved method employing hypothetical grains described in the previous paper have been used to analyze the distribution of autoradiographic grains over erythroid bone marrow cells labeled with radioactive iron, 55Fe. The resolution obtainable with this isotope was determined by measuring the distribution of grains about a thin line source. This distribution was also used in calculation of the circle size for the Williams's analysis and the distances of hypothetical grains for the new method. The new method provides estimates for the amount of activity in the regions of condensed and extended nuclear chromatin and for the concentration of isotope at the junction between these two areas. The possible significance of activity in this junctional region is discussed.

Submitted on May 24, 1972
Revised on November 13, 1972


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