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The Journal of Cell Biology, Vol 68, 793-798, Copyright © 1976 by The Rockefeller University Press

ARTICLES

In vivo induction of tight junction proliferation in rat liver

R Montesano, G Gabbiani, A Perrelet and L Orci

The chronic administration of phalloidin induces an extensive development of tight junctions between rat hepatocytes. The junctional strands lose their predominantly parallel orientation with respect to the canalicular lumen and extend abluminally in irregular patterns which cover large membrane areas at considerable distance from the bile canaliculi. These changes indicate both proliferation and provide further evidence that these junctions are not permanent differentiations of the cell membrane.
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