Adhesion among neural cells of the chick embryo. III. Relationship of the surface molecule CAM to cell adhesion and the development of histotypic patterns

doi:10.1083/jcb.79.2.371

This Article

	PDF (Full Text)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Rutishauser, U.
	Articles by Edelman, G. M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Rutishauser, U.
	Articles by Edelman, G. M.


Social Bookmarking

	What's this?

ARTICLES

Adhesion among neural cells of the chick embryo. III. Relationship of the surface molecule CAM to cell adhesion and the development of histotypic patterns

U Rutishauser, JP Thiery, R Brackenbury and GM Edelman

We have previously identified a molecule (named cell adhesion molecule [CAM]) that is involved in the in vitro aggregation of neural cells from chick embryos. In the present report, specific anti-CAM antibodies have been used to demonstrated that CAM is localized in neural tissues, and is associated with the plasma membrane of retinal cells and neurites. Furthermore, it has been shown by antibody absorption techniques that the decreased adhesiveness of cultured retinal cells obtained originally from older embryos is correlated with a decrease in the density or accessibility of cell adhesion molecules on the surface of these cells. The central role of CAM in neural cell aggregation has been established by the observation that anti-CAM Fab' fragments inhibit adhesion between neural cells in a variety of assays. To investigate the function of CAM and cell adhesion in developing tissues, aggregates of retinal cells that are capable of forming histotypic patterns in vitro were cultured in the presence and absence of anti-CAM Fab'. The Fab' was found to inhibit sorting out of cell bodies and neurites and to decrease the number of membrane-membrane contacts, suggesting that CAM is associated with cell-cell, cell- neurite, and neurite-neurite interactions.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Powell, K. (2005). The sticky business of discovering cadherins. JCB 170: 514-514 [Full Text]
Burden-Gulley, S. M., Brady-Kalnay, S. M. (1999). PTP� Regulates N-Cadherin-dependent Neurite Outgrowth. JCB 144: 1323-1336 [Abstract] [Full Text]
Thompson, J, Dickson, G, Moore, S E, Gower, H J, Putt, W, Kenimer, J G, Barton, C H, Walsh, F S (1989). Alternative splicing of the neural cell adhesion molecule gene generates variant extracellular domain structure in skeletal muscle and brain.. Genes Dev. 3: 348-357 [Abstract]
BERLOT, J., GOODMAN, C. S. (1984). Guidance of Peripheral Pioneer Neurons in the Grasshopper: Adhesive Hierarchy of Epithelial and Neuronal Surfaces. Science 223: 493-496 [Abstract]
Grumet, M, Rutishauser, U, Edelman, G. (1983). Neuron-glia adhesion is inhibited by antibodies to neural determinants. Science 222: 60-62 [Abstract]
Edelman, G. (1983). Cell adhesion molecules. Science 219: 450-457 [Abstract]
Rutishauser, U. (1983). Molecular and Biological Properties of a Neural Cell Adhesion Molecule. Cold Spring Harb Symp Quant Biol 48: 501-514 [Abstract]
Gall, W., Edelman, G. (1981). Lateral diffusion of surface molecules in animal cells and tissues. Science 213: 903-905 [Abstract]
Sheffield, J., Pressman, D, Lynch, M (1980). Cells isolated from the embryonic neural retina differ in behavior in vitro and membrane structure. Science 209: 1043-1045 [Abstract]
Rusoff, A., Easter, S. Jr (1980). Order in the optic nerve of goldfish. Science 208: 311-312 [Abstract]