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The Journal of Cell Biology, Vol 80, 197-202, Copyright © 1979 by The Rockefeller University Press

ARTICLES

Epidermal cells adhere preferentially to type IV (basement membrane) collagen

JC Murray, G Stingl, HK Kleinman, GR Martin and SI Katz

Epidermal cells from adult guinea pig skin attach and differentiate preferentially on substrates of type IV (basement membrane) collagen, compared to those of types I--III collagen. In contrast, guinea pig dermal fibroblasts attach equally well to all four collagen substrates. Fibronectin mediates the attachment of fibroblasts but not of epidermal cells to collagen.
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