A large particle associated with the perimeter of the nuclear pore complex

doi:10.1083/jcb.93.1.63

This Article

	Full Text (PDF, 2210K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JCB
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Unwin, P. N.
	Articles by Milligan, R. A.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Unwin, P. N.
	Articles by Milligan, R. A.


Social Bookmarking

	What's this?

ARTICLES

A large particle associated with the perimeter of the nuclear pore complex

PN Unwin and RA Milligan

The three-dimensional structure of the nuclear pore complex has been determined to a resolution of approximately 90 A by electron microscopy using nuclear envelopes from Xenopus oocytes. It is shown to be an assembly of several discrete constituents arranged with octagonal symmetry about a central axis. There are apparent twofold axes perpendicular to the octad axis which suggest that the framework of the pore complex is constructed from two equal but oppositely facing halves. The half facing the cytoplasm is in some instances decorated by large particles, similar in appearance and size to ribosomes.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Add to Reddit Reddit Add to Technorati Technorati What's this?

This article has been cited by other articles:

Leslie, M. (2005). A portrait of the nuclear pore complex. JCB 171: 194-195 [Full Text]
Kiseleva, E., Rutherford, S., Cotter, L. M., Allen, T. D., Goldberg, M. W. (2002). Steps of nuclear pore complex disassembly and reassembly during mitosis in early Drosophila embryos. J. Cell Sci. 114: 3607-3618 [Abstract] [Full Text]
Wente, S. R. (2000). Gatekeepers of the Nucleus. Science 288: 1374-1377 [Abstract] [Full Text]
Strambio-de-Castillia, C., Blobel, G., Rout, M. P. (1999). Proteins Connecting the Nuclear Pore Complex with the Nuclear Interior. JCB 144: 839-855 [Abstract] [Full Text]
Hurt, E., Hannus, S., Schmelzl, B., Lau, D., Tollervey, D., Simos, G. (1999). A Novel In Vivo Assay Reveals Inhibition of Ribosomal Nuclear Export in Ran-Cycle and Nucleoporin Mutants. JCB 144: 389-401 [Abstract] [Full Text]
Hurwitz, M. E., Strambio-de-Castillia, C., Blobel, G. (1998). Two yeast nuclear pore complex proteins involved in mRNA export form a cytoplasmically oriented subcomplex. Proc. Natl. Acad. Sci. USA 95: 11241-11245 [Abstract] [Full Text]
Kiseleva, E, Goldberg, M., Allen, T., Akey, C. (1998). Active nuclear pore complexes in Chironomus: visualization of transporter configurations related to mRNP export. J. Cell Sci. 111: 223-236 [Abstract]
Delphin, C., Guan, T., Melchior, F., Gerace, L. (1997). RanGTP Targets p97 to RanBP2, a Filamentous Protein Localized at the Cytoplasmic Periphery of the Nuclear Pore Complex. Mol. Biol. Cell 8: 2379-2390 [Abstract] [Full Text]
Grandi, P., Dang, T., Pané, N., Shevchenko, A., Mann, M., Forbes, D., Hurt, E. (1997). Nup93, a Vertebrate Homologue of Yeast Nic96p, Forms a Complex with a Novel 205-kDa Protein and Is Required for Correct Nuclear Pore Assembly. Mol. Biol. Cell 8: 2017-2038 [Abstract] [Full Text]
Del Priore, V, Heath, C, Snay, C, MacMillan, A, Gorsch, L, Dagher, S, Cole, C (1997). A structure/function analysis of Rat7p/Nup159p, an essential nucleoporin of Saccharomyces cerevisiae. J. Cell Sci. 110: 2987-2999 [Abstract]
Goldberg, M., Wiese, C, Allen, T., Wilson, K. (1997). Dimples, pores, star-rings, and thin rings on growing nuclear envelopes: evidence for structural intermediates in nuclear pore complex assembly. J. Cell Sci. 110: 409-420 [Abstract]
Perez-Terzic, C., Pyle, J., Jaconi, M., Stehno-Bittel, L., Clapham, D. E. (1996). Conformational States of the Nuclear Pore Complex Induced by Depletion of Nuclear Ca2+ Stores. Science 273: 1875-1877 [Abstract] [Full Text]
Grote, M, Kubitscheck, U, Reichelt, R, Peters, R (1995). Mapping of nucleoporins to the center of the nuclear pore complex by post-embedding immunogold electron microscopy. J. Cell Sci. 108: 2963-2972 [Abstract]
Chugani, D., Rome, L., Kedersha, N. (1993). Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex. J. Cell Sci. 106: 23-29 [Abstract]
Goldberg, M., Allen, T. (1993). The nuclear pore complex: three-dimensional surface structure revealed by field emission, in-lens scanning electron microscopy, with underlying structure uncovered by proteolysis. J. Cell Sci. 106: 261-274 [Abstract]