JCB logo
BD Biosciences
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 1 October 2001. doi:10.1083/jcb1551iti5
This Article
Right arrow PDF (Full Text)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dove, A. W.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Dove, A. W.
Related Collections
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
© The Rockefeller University Press, 0021-9525/2001/10/11-b $5.00
The Journal of Cell Biology, Volume 155, Number 1, October 1, 2001 11-b-11

In This Issue

 Disgorging the MVB
A transformation from blobs (top) to tubules (bottom) helps load antigen.

The multivesicular body (MVB), a cluster of vesicles surrounded by a limiting membrane, is a ubiquitous but poorly understood structure in eukaryotic cells. On page 53,Kleijmeer et al. present the first evidence that the MVB can be used as a temporary storage depot for membranes and membrane proteins, which can then be deployed rapidly to the surface of the cell. The work also helps to explain how certain antigens are presented to initiate a primary T cell response. Previous work on this problem had left a basic topological question unresolved: how does antigen-presenting MHC II move from the internal vesicles of the MVB to the exterior surface of the plasma membrane?

The authors found that in immature cultured dendritic cells, MHC II is concentrated in the internal vesicles of MVBs, while the peptide-loading accessory molecule DM is found mostly in the MVB limiting membrane. When the cells are activated, the internal vesicles fuse with the limiting membrane, presumably allowing DM to load antigen onto the MHC. The MVB then elongates into a tubular structure that extends toward the plasma membrane. Vesicles containing both MHC II and DM bud from the tip of this structure, possibly ending up at the cell surface where antigens are displayed. {blacksquare}



Alan W. Dove

alanwdove{at}earthlink.net


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article

Reorganization of multivesicular bodies regulates MHC class II antigen presentation by dendritic cells
Monique Kleijmeer, Georg Ramm, Danita Schuurhuis, Janice Griffith, Maria Rescigno, Paola Ricciardi-Castagnoli, Alexander Y. Rudensky, Ferry Ossendorp, Cornelis J.M. Melief, Willem Stoorvogel, and Hans J. Geuze
J. Cell Biol. 2001 155: 53-64. [Abstract] [Full Text] [PDF]




This Article
Right arrow PDF (Full Text)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Alert me to new content in the JCB
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dove, A. W.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Dove, A. W.
Related Collections
Right arrowRelated Article
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents