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Published 3 January 2005. doi:10.1083/jcb1681iti3
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 168, Number 1, 9-9
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 p107 Skps from S phase


Overexpressed p107 (open boxes) makes Skp2 unstable.

Pocket proteins find multiple routes to stop cell proliferation, according to results on page 55, from Rodier et al.The well-known antiproliferative route taken by pocket proteins, including pRb and p107, is through interaction with E2F. When bound to pRb, E2F cannot initiate the transcription of cell cycle progression genes, and cells thus linger in G1.



Nicole LeBrasseur

lebrasn{at}rockefeller.edu


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Related Article

p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2
Geneviève Rodier, Constantin Makris, Philippe Coulombe, Anthony Scime, Keiko Nakayama, Keiichi I. Nakayama, and Sylvain Meloche
J. Cell Biol. 2005 168: 55-66. [Abstract] [Full Text] [PDF]




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