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One Centrin2 (green) lobe associates with the old Golgi (red, A), the other with the new Golgi (B). The bi-lobed structure then separates and duplicates (C and D). WARREN/AAAS

Centrin that is not on centrosomes may help control Golgi duplication, say Cynthia He, Marc Pypaert, and Graham Warren (Yale University, New Haven, CT).Centrins are essential components of centrosomes, which are well-known microtubule organizers. They are less well-known as organelle replicators—apicoplasts and kinetoplasts rely on centrosomes to duplicate in protozoans. Those organisms "are just protists," says He. "So no one really paid attention [to the findings]." But she imagined they might mean that centrosomes also control Golgi replication.

She was on the right track, as the group found that loss of trypanosomal Centrin2 inhibited Golgi duplication. It was not, however, doing this job from the centrosome, but rather from an odd bi-lobed cytoplasmic structure. One lobe was associated with the cell's only Golgi stack. The second lobe was free during early interphase, but later was associated with the newly forming Golgi stack.

Centrin is phosphorylated by PKA in a cell cycle–regulated manner, which might determine when the new stack is seeded. Alternatively, centrin might help separate duplicated stacks, as algal Centrin is known to be part of an ancient contractile system. Centrin might also control the duplication of the bi-lobed structure itself, an event that occurred after Golgi duplication and led to two bi-lobed structures, each with a single Golgi stack.

"Mammalian centrins," says He, "form a pericentrosomal haze reminiscent of the Golgi ribbon." This haze was considered to be insignificant centrosomal overflow, but with the new findings it warrants a closer examination.

Reference:

He, C.Y., et al. 2005. Science. doi:10.1126/science.1119969.[Abstract/Free Full Text]

Nicole LeBrasseur

lebrasn{at}rockefeller.edu

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This Article PDF (Full Text) PPT slides of all figures Alert me when this article is cited Services Email this article Similar articles in this journal Alert me to new content in the JCB Download to citation manager Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by LeBrasseur, N. Search for Related Content PubMed Articles by LeBrasseur, N. Social Bookmarking                      What's this?