Published online 2 October 2006. doi:10.1083/jcb.1751iti4
The Rockefeller University Press, 0021-9525 $8.00
JCB, Volume 175, Number 1, 3-3
Ring around the tubule
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Coils of kinesin-13 (arrows) surround a microtubule.
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The kinesin protein family is in the trucking business, hauling vesicles and other cellular cargo along the microtubules. The family's black sheep is kinesin-13, which disassembles the filaments while riding on them. Tan et al. report on page 25 that kinesin-13 is unusual in another way. The protein forms rings and spirals around microtubules. The structures might help it maintain its position as a tubule shrinks.
By shortening microtubules, kinesin-13 helps chromosomes to go their separate ways during mitosis. But how kinesin-13 performs the job is mysterious. The researchers spotted the rings and spirals when they combined microtubules with the motor domain of kinesin-13, the protein segment that latches onto the filament. Other types of kinesin did not coil up, the scientists showed. Molecular reconstructions suggest that each ring consists of several kinesin-13 molecules encircled by a strand of free tubulin, the building block of microtubules.
Why kinesin-13 gets into a twist is not certain, but Tan et al. speculate that the formation slides along the microtubule like a sleeve, keeping kinesin-13 at the end of the shortening tubule. To test that possibility, the researchers tagged kinesin-13 with green fluorescent protein. As the microtubule depolymerized, its tip glowed brighter, indicating that the rings were bunching up at the end. 
Mitch Leslie
mitchleslie{at}comcast.net
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Kinesin-13s form rings around microtubules
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