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Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200308060
Markevich et al.
• Figure S1 Simulation of the time course of tyrosine and threonine phosphorylation of p42 MAPK by MAPKK.
• Figure S2 Bifurcation diagram for the elementary steps description of MAPK phosphorylation-dephosphorylation cycle on the k1cat , k2cat plane.
• Figure S3 Hill-type approximation of emerging product activation in the ERK cycle.
• Figure S4 Bifurcation diagrams for the elementary step description of the ERK cycle in the plane of the total concentrations (activities) of MEK and MKP3 at different total ERK concentrations (Mtot).
• Figure S5 Steady-state responses of bisphosphorylated ERK to the total MEK concentration (activity).
• Figure S6 Dual phosphorylation-dephosphorylation cycle of MAPK (M), in which both MAPK kinase (MAPKK) and MAPK phosphatase (MKP) follow distributive random kinetic mechanisms.
• Figure S7 Bifurcation diagram for the MAPK phosphorylation cycle in the plane of the activities (total concentrations) of the kinase and phosphatase.
• Figure S8 Hysteresis and multistability in the MAPK cascade arising from the bistable behavior of individual cycles of dual phosphorylation and dephosphorylation.
• Figure S9 Bistability in a cycle where MAPK (M) is phosphorylated by two different kinases (MAPKK1 and MAPKK2) and dephosphorylated by a single phosphatase.
• Tables S1-S4 (PDF)
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