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Index of Online Supplemental Material for
J. Cell Biol. 10.1083/jcb.200708130
Mangahas et al.
• Figure S1 Ced and Unc phenotypes are a result of the loss of unc-108 function.
• Figure S2 Structural modeling of GTP-bound conformations of wild-type and mutant UNC-108 proteins.
• Figure S3 Genetic interaction studies between unc-108 and engulfment ced genes.
• Figure S4 2× FYVE as a specific marker for engulfed cell corpses.
• Figure S5 The initial presentation of PI(3)P is unaffected in unc-108(n3263) mutants.
• Video 1 The engulfment of cell corpse C3 in a wild-type animal.
• Video 2 Engulfment of cell corpse C3 in is prolonged in unc-108(n3263).
• Video 3 Degradation of cell corpse C2 in wild type.
• Video 4 Degradation of cell corpse C2 is defective in unc-108(n3263).
• Video 5 GFP::UNC-108 is transiently enriched around the phagosome containing cell corpse C2.
• Video 6 GFP::UNC-108(G13Q) displays abnormal cytoplasmic localization and is not recruited to the phagosome containing cell corpse C2.
• Video 7 Lysosomes are recruited to the phagosome containing cell corpse C2 in the wild type.
• Video 8 Lysosome recruitment to the phagosome containing cell corpse C2 is defective in unc-108(n3263).
• Video 9 Lysosome recruitment to the phagosome containing cell corpse C2 is delayed in unc-108(n3263).
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