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Published online March 31, 2008
doi:10.1083/jcb.200802155
The Journal of Cell Biology, Vol. 181, No. 1, 9-13
The Rockefeller University Press, 0021-9525 $30.00
© 2008 Meshorer et al.
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 Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging

Eran Meshorer and Yosef Gruenbaum

Department of Genetics, Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel

Correspondence to Eran Meshorer: meshorer{at}cc.huji.ac.il; or Yosef Gruenbaum: gru{at}vms.huji.ac.il

Specific mutations in the human gene encoding lamin A or in the lamin A–processing enzyme, Zmpste24, cause premature aging. New data on mice and humans suggest that these mutations affect adult stem cells by interfering with the Notch and Wnt signaling pathways.


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