About the Cover
Cover picture: Freeze-fracture replica images of TJs in MDCK I cells incubated with C-CPE. At 0, 4, or 8 h after incubation with 2.5 mg/ml C-CPE in the basolateral compartment, MDCK I cells plated at confluent density on filters were fixed with glutaraldehyde, and processed for freeze-fracture replica electron microscopy. In the absence of C-CPE, MDCK I cells were characterized by well-developed anastomosing networks of TJ strands. At 4 h after incubation with CCPE, TJ strands facing toward the basolateral membrane domains began to disintegrate to thick belt-like aggregates of intramembranous particles. Around 8 h incubation, these belt-like particle aggregates had mostly disappeared, leaving a fairly simple TJ strand network. See related article in this issue by Sonoda et al., 195-204.
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