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Cover Figure


>Cover picture: Yeast mating pairs lacking Prm1p, a pheromone-regulated membrane protein, exhibit a unique mating defect. The mating pair on the right is caught in the act of degrading the cell wall separating mating partners, the step at which all other fusion mutants arrest. However, as seen in the mating pair on the left, deltaprm1 mutants proceed to complete cell wall breakdown, but then fail to perform plasma membrane fusion, resulting in a bubble of tightly apposed, unfused membranes. This phenotype defines a new step in the cell fusion pathway. See related article in this issue by Heiman et al., 719-730.
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