http://www.jcb.org The Journal of Cell Biology RSS feed -- recent Comments articles 1540-8140 The Journal of Cell Biology 0021-9525 http://www.jcb.org/icons/banner/title.gif http://www.jcb.org http://www.jcb.org/cgi/content/short/181/4/575?rss=1 Schwann cells are remarkably plastic cells that can both form and stably maintain myelin sheaths around axons and also rapidly dedifferentiate upon injury. New findings (Parkinson, D.B., A. Bhaskaran, P. Arthur-Farraj, L.A. Noon, A. Woodhoo, A.C. Lloyd, M.L. Feltri, L. Wrabetz, A. Behrens, R. Mirsky, and K.R. Jessen. 2008. J. Cell Biol. 181:625–637) indicate that the transition between these distinct states of differentiation is directed by the transcription factor Krox-20, which promotes and maintains myelination, and c-Jun, which antagonizes it. Cross-inhibition of these transcription factors serves to switch Schwann cells between the myelinated and dedifferentiated phenotypes, respectively.

]]> 2008-05-19 info:doi/10.1083/jcb.200804136 The Rockefeller University Press 4 181 577 2008-05-19 575 Comments